UniProt AC | UniProt Status | Protein Name | Organism | PMID | Article Title | Category | Annotation | Contributor | ![]() | Submission Date | |
P22455 | Reviewed | Fibroblast growth factor receptor 4 | Homo sapiens (Human). | 29438108 | STAT3-enhancing germline mutations contribute to tumor-extrinsic immune evasion. | [Pathology & Biotech][Sequence] | Protein/gene_name: Fibroblast growth factor receptor 4; FGFR4; CD334. Function: FGFR4 p.G388R variant increases phosphorylation of STAT3 (at Tyr-705) and thereby enhances STAT3 signaling in CD4(+)CD25(+)FOXP3(+) regulatory T cells in rs351855-A allele SNP knock-in mice; thereby suppresses the expansion of CD8 T cells in the lymph nodes and tumor milieu. Additional Annotation: FGFR4 is highly expressed in CD8 T cells and CD4(+)CD25(+)FOXP3(+) T cells. | Vijay Kumar Ulaganathan | 0000-0002-4717-6228 | 2021-6-2 |