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UniProt AC
UniProt Status
Protein Name
Organism
PMID
Article Title
Category
Annotation
Contributor
ORCID logoORCID
Submission Date
P22455ReviewedFibroblast growth factor receptor 4 Homo sapiens (Human).29438108STAT3-enhancing germline mutations contribute to tumor-extrinsic immune evasion.[Pathology & Biotech][Sequence]Protein/gene_name: Fibroblast growth factor receptor 4; FGFR4; CD334.
Function: FGFR4 p.G388R variant increases phosphorylation of STAT3 (at Tyr-705) and thereby enhances STAT3 signaling in CD4(+)CD25(+)FOXP3(+) regulatory T cells in rs351855-A allele SNP knock-in mice; thereby suppresses the expansion of CD8 T cells in the lymph nodes and tumor milieu.
Additional Annotation: FGFR4 is highly expressed in CD8 T cells and CD4(+)CD25(+)FOXP3(+) T cells.
Vijay Kumar Ulaganathan0000-0002-4717-62282021-6-2