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UniProt AC
UniProt Status
Protein Name
Organism
PMID
Article Title
Category
Annotation
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ORCID logoORCID
Submission Date
Q9H257ReviewedCaspase recruitment domain-containing protein 9 Homo sapiens (Human).32790937Defining the combinatorial space of PKC::CARD-CC signal transduction nodes.[Function][PTM / Processing]Protein/gene_name: CARD9.
Function: Mutagenesis: CARD9 T231A abolishes activation by several upstream PKCs (alpha, delta, epsilon, theta, eta).
Jens Staal0000-0003-2664-33572021-9-3
Q9H257ReviewedCaspase recruitment domain-containing protein 9 Homo sapiens (Human).30429846A CARD9 Founder Mutation Disrupts NF-κB Signaling by Inhibiting BCL10 and MALT1 Recruitment and Signalosome Formation.[Function][Pathology & Biotech][Sequence]Protein/gene_name: CARD9.
Function: Mutagenesis R70W abolishes BCL10 recruitment and downstream NF-kappa-B activation. Mutagenesis L213LI relieves autoinhibition and leads to activation of NF-kappa-B. Mutagenesis Q419* relieves autoinhibition and leads to activation of NF-kappa-B.
Jens Staal0000-0003-2664-33572021-9-3