UniProt AC | UniProt Status | Protein Name | Organism | PMID | Article Title | Category | Annotation | Contributor | ORCID | Submission Date | |
Q9H257 | Reviewed | Caspase recruitment domain-containing protein 9 | Homo sapiens (Human). | 32790937 | Defining the combinatorial space of PKC::CARD-CC signal transduction nodes. | [Function][PTM / Processing] | Protein/gene_name: CARD9. Function: Mutagenesis: CARD9 T231A abolishes activation by several upstream PKCs (alpha, delta, epsilon, theta, eta). | Jens Staal | 0000-0003-2664-3357 | 2021-9-3 | |
Q9H257 | Reviewed | Caspase recruitment domain-containing protein 9 | Homo sapiens (Human). | 30429846 | A CARD9 Founder Mutation Disrupts NF-κB Signaling by Inhibiting BCL10 and MALT1 Recruitment and Signalosome Formation. | [Function][Pathology & Biotech][Sequence] | Protein/gene_name: CARD9. Function: Mutagenesis R70W abolishes BCL10 recruitment and downstream NF-kappa-B activation. Mutagenesis L213LI relieves autoinhibition and leads to activation of NF-kappa-B. Mutagenesis Q419* relieves autoinhibition and leads to activation of NF-kappa-B. | Jens Staal | 0000-0003-2664-3357 | 2021-9-3 |