Vaccinia virus E3 prevents sensing of Z-RNA to block ZBP1-dependent necroptosis.
[Function][Pathology & Biotech][Interaction]
Protein/gene_name: ZBP1. Function: It is a specialized sensor for Z-RNA that is generated early during virus infection. Sensing of the Z-RNA PAMP activates virus-induced necroptosis resulting in early control of orthopoxvirus infection.