UniProt AC | UniProt Status | Protein Name | Organism | PMID | Article Title | Category | Annotation | Contributor | ORCID | Submission Date | |
A0A0D1DWZ5 | Reviewed | RNA-binding protein RRM4 | Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus). | 35727840 | A MademoiseLLE domain binding platform links the key RNA transporter to endosomes. | [Function][Subcellular location][Expression][Interaction][Structure][Sequence] | Protein/gene_name: Rrm4. Function: It is a key mRNA transporting protein, mediating the mRNA transport to the growing tip of the cell. Additional Annotation: It has three RRM domains at the N terminal and three MLLE domains at the C terminal. These three MLLE domains make a binding platform that facilitates multiple protein-protein interactions. Rrm4 is tethered to the cytoplasmic surface of the endosomes by interacting with the adaptor protein Upa1. Third MLLE domain of Rrm4 interacts with the PAM2L1 and PAM2L2 motifs present in the Upa1. Loss of this interaction leads to severe growth defects and bipolar growth phenotype. Loss of MLLE2 leads to aberrant accumulation of Rrm4 on the microtubule cytoskeleton. Subcellular location: Rrm4 is localized on the cytoplasmic surface of the endosomes. | Senthil-Kumar Devan | 0000-0003-1680-1630 | 2022-8-13 | |
A0A0D1DWZ5 | Reviewed | RNA-binding protein RRM4 | Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus). | 19494833 | The fungal RNA-binding protein Rrm4 mediates long-distance transport of ubi1 and rho3 mRNAs. | [Function][Subcellular location][Expression][Interaction][Sequence] | Protein/gene_name: Rrm4; rrm4; UMAG_10836. Function: Key RNA binding protein for microtubule-dependent mRNA transport. Additional Annotation: The fungal RNA-binding protein Rrm4 mediates long-distance transport of ubi1 and rho3 mRNAs. | Senthil Kumar Devan | 0000-0003-1680-1630 | 2021-8-5 | |
A0A0D1DWZ5 | Reviewed | RNA-binding protein RRM4 | Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus). | 25985087 | A FYVE zinc finger domain protein specifically links mRNA transport to endosome trafficking. | [Function][Subcellular location][Expression][Interaction][Sequence] | Protein/gene_name: Rrm4; rrm4; UMAG_10836. Function: Key RNA binding protein for endosome meditated mRNA transport. Additional Annotation: The key factor Rrm4 contains three N-terminal RRMs (RNA recognition motifs) and two C-terminal MademoiseLLE domains (MLLE, also known as PABC, poly(A)-binding protein C-terminal domain which serve as a protein-protein interaction pocket for specific interaction with two PAM2-like motifs present in the adaptor protein Upa1. | Senthil Kumar Devan | 0000-0003-1680-1630 | 2021-8-5 | |
A0A0D1DWZ5 | Reviewed | RNA-binding protein RRM4 | Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus). | 30738139 | Core components of endosomal mRNA transport are evolutionarily conserved in fungi. | [Function][Subcellular location][Expression][Interaction][Sequence] | Protein/gene_name: Rrm4; rrm4; UMAG_10836. Function: Key RNA binding protein for endosome meditated mRNA transport. Additional Annotation: Hitchhiking on the cytoplasmic surface of Rab5a-positive endosomes. It is a posttranscriptional regulator and shuttles intensively along microtubules and binds thousands of mRNAs. | Senthil Kumar Devan | 0000-0003-1680-1630 | 2021-8-5 | |
A0A0D1DWZ5 | Reviewed | RNA-binding protein RRM4 | Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus). | 30552148 | The key protein of endosomal mRNP transport Rrm4 binds translational landmark sites of cargo mRNAs. | [Function][Subcellular location][Expression][Interaction][Sequence] | Protein/gene_name: Rrm4; rrm4; UMAG_10836. Function: Key RNA binding protein for endosome meditated mRNA transport. Additional Annotation: Subscellular localization: Early endosomes. | Senthil Kumar Devan | 0000-0003-1680-1630 | 2021-8-5 | |
A0A0D1DWZ5 | Reviewed | RNA-binding protein RRM4 | Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus). | 17105762 | The RNA-binding protein Rrm4 is essential for polarity in Ustilago maydis and shuttles along microtubules. | [Function][Subcellular location][Expression][Sequence] | Protein/gene_name: Rrm4; rrm4; UMAG_10836. Function: Key RNA binding protein for endosome meditated mRNA transport. Additional Annotation: Subscellular localization: Early endosomes. | Senthil Kumar Devan | 0000-0003-1680-1630 | 2021-8-5 |