UniProt AC | UniProt Status | Protein Name | Organism | PMID | Article Title | Category | Annotation | Contributor | ORCID | Submission Date | |
B0L3A2 | Reviewed | Dual endothelin-1/VEGF signal peptide receptor | Homo sapiens (Human). | 35379853 | A targetable 'rogue' neutrophil-subset, [CD11b+DEspR+] immunotype, is associated with severity and mortality in acute respiratory distress syndrome (ARDS) and COVID-19-ARDS. | [Pathology & Biotech][Expression] | Protein/gene_name: DEspR. Disease: DEspR+CD11b+ neutrophils are increased and associated with severity and poor outcomes in patients with acute respiratory distress syndrome and COVID-19. NET-forming neutrophils in the circulation are DEspR+. | Anonymous | Anonymous | 2023-4-10 | |
B0L3A2 | Reviewed | Dual endothelin-1/VEGF signal peptide receptor | Homo sapiens (Human). | 36275710 | "Rogue" neutrophil-subset [DEspR+CD11b+/CD66b+] immunotype is an actionable therapeutic target for neutrophilic inflammation-mediated tissue injury - studies in human, macaque and rat LPS-inflammation models. | [Function][Pathology & Biotech] | Protein/gene_name: DEspR. Function: DEspR+ neutrophils are increased by bacteriotoxin lipopolysaccharide (LPS)-TLR4 activation. Disease: Intrabronchial instillation of LPS induces DEspR+CD66b+ neutrophils in the broncholavage fluid. | Anonymous | Anonymous | 2023-4-10 | |
B0L3A2 | Reviewed | Dual endothelin-1/VEGF signal peptide receptor | Homo sapiens (Human). | 36007264 | Expression of DEspR in acute intracerebral hemorrhage. | [Pathology & Biotech][Expression] | Protein/gene_name: DEspR. Disease: DEspR+ neutrophil levels are associated with hypertension in patients at acute spontaneous intracerebral hemorrhage. | Anonymous | Anonymous | 2023-4-10 | |
B0L3A2 | Reviewed | Dual endothelin-1/VEGF signal peptide receptor | Homo sapiens (Human). | 35959408 | "Rogue" [DEspR+CD11b+] neutrophil subset correlates with severity in spontaneous intracerebral hemorrhage. | [Function][Pathology & Biotech][Expression] | Protein/gene_name: DEspR. Function: DEspR is expressed on activated CD11b+ neutrophils. DEspR+CD11b+ neutrophil levels correlate with the neutrophil lymphocyte ratio (NLR) and circulating levels of NET-forming neutrophils. Disease: DEspR+ CD11b+ neutrophil levels increase at acute spontaneous intracerebral hemorrhage (sICH). DEspR+CD11b+ neutrophil levels are associated with severity clinical indicators and poor outcomes in sICH. | Anonymous | Anonymous | 2023-4-10 | |
B0L3A2 | Reviewed | Dual endothelin-1/VEGF signal peptide receptor | Homo sapiens (Human). | 34789851 | DEspRhigh neutrophils are associated with critical illness in COVID-19. | [Subcellular location][Expression] | Protein/gene_name: DEspR; dual endothelin-1/signal peptide of pro-VEGF receptor. Function: A neutrophil-subset in COVID19 patients expresses DEspR. DEspR[high] neutrophils are associated with critical illness in COVID19. Additional Annotation: Identification of DEspR expression in non-tumor cells, i.e., activated neutrophil-subset associated with critical illness in COVID19. | Victoria Herrera | 0000-0001-8991-2134 | 2021-12-9 | |
B0L3A2 | Reviewed | Dual endothelin-1/VEGF signal peptide receptor | Homo sapiens (Human). | 33853558 | Humanized anti-DEspR IgG4S228P antibody increases overall survival in a pancreatic cancer stem cell-xenograft peritoneal carcinomatosis ratnu/nu model. | [Function][Subcellular location][Pathology & Biotech][Expression] | Protein/gene_name: Dual Endothelin-1/signal peptide of VEGF-propeptide Receptor; DEspR. Function: It contributes to apoptosis resistance of pancreatic cancer stem-like cells (CSCs) and nonCSC-tumor cells. DEspR-inhibition attenuates pancreatic tumor cell dissemination in the intraperitoneal space, increasing median overall survival in xenograft nude rat model of pancreatic peritoneal carcinomatosis. DEspR-inhibition of Panc1-derived CSCs decreases xenograft tumor establishment of heterotopic flank tumor and peritoneal metastatic tumors. DEspR is not expressed in tumor-adjacent normal tissues. Disease: Pancreatic cancer peritoneal carcinomatosis. Additional Annotation: Non-detection in normal adult tissues (except for human placenta, kidney, angiogenic HUVECs) is not evidence for non-existence of the DEspR protein. Presence in cancer cells and absence in normal cells (except for placenta, kidney, angiogeneic endothelial HUVECs) is key for safety of anti-DEspR tumor-cell targeted therapy premised on sparing normal adult tissues. | Victoria Herrera | 0000-0001-8991-2134 | 2021-12-9 |