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UniProt AC
UniProt Status
Protein Name
Organism
PMID
Article Title
Category
Annotation
Contributor
ORCID logoORCID
Submission Date
D3Z596UnreviewedInsulin II Mus musculus (Mouse).37967211Top-Down Proteomics of Mouse Islets With Beta Cell CPE Deletion Reveals Molecular Details in Prohormone Processing.[Expression]
Additional Annotation: Expression of alternatively spliced INS2 D3Z596 in pancreatic islets.
James Michael Fulcher0000-0001-9033-36232024-10-3
D3Z596UnreviewedInsulin II Mus musculus (Mouse).36266275Combining mass spectrometry and machine learning to discover bioactive peptides.[Function][PTM / Processing][Expression][Sequence]
Function: Alternative splicing decouples B- and A-chain configuration, to only form B-chain and a new reading frame creating D-peptide.
Additional Annotation: Splicing event only observed in pancreas. Comments: Alternative splicing event creating a new peptide (D-peptide) in insulin-2. Mass spectrometry verification of the peptide.
Christian Toft Madsen0000-0003-3268-53502022-11-10