UniProt AC | UniProt Status | Protein Name | Organism | PMID | Article Title | Category | Annotation | Contributor | ORCID | Submission Date | |
F5HF68 | Reviewed | VIRF-1 | Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus). | 20700448 | Bim nuclear translocation and inactivation by viral interferon regulatory factor. | [Function][Subcellular location][Pathology & Biotech][Interaction] | Protein/gene_name: VIRF-1; HHV-8 K9. Function: In host cells, VIRF-1 binds to and sequesters BimEL into the nucleus to inhibit BimEL-induced apoptosis. Disease: HHV-8 associated malignancies including Primary Effusion Lymphoma and Kaposi's sarcoma. Additional Annotation: Subcellular location: Host nucleus. | Young Bong Choi | 0000-0002-2523-1441 | 2020-12-2 | |
F5HF68 | Reviewed | VIRF-1 | Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus). | 22685405 | Human herpesvirus 8 interferon regulatory factor-mediated BH3-only protein inhibition via Bid BH3-B mimicry. | [Function][Subcellular location][Interaction] | Protein/gene_name: VIRF-1; HHV-8 K9. Function: In host cells, VIRF-1 binds to BID and inhibits BID-induced apoptosis. Disease: HHV-8 associated malignancies including Primary Effusion Lymphoma and Kaposi's sarcoma. Additional Annotation: Subcellular location: Host mitochondrion. | Young Bong Choi | 0000-0002-2523-1441 | 2020-12-2 | |
F5HF68 | Reviewed | VIRF-1 | Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus). | 26512076 | Modulation of Mitochondrial Antiviral Signaling by Human Herpesvirus 8 Interferon Regulatory Factor 1. | [Function][Subcellular location][Pathology & Biotech][Interaction] | Protein/gene_name: VIRF-1; HHV-8 K9. Function: In host cells, VIRF-1 localizes to mitochondria and inhibits MAVS-mediated antiviral signaling. Disease: HHV-8-associated malignancies including Primary Effusion Lymphoma and Kaposi's sarcoma. Additional Annotation: Subcellular location: Host mitochondrion. | Young Bong Choi | 0000-0002-2523-1441 | 2020-12-2 | |
F5HF68 | Reviewed | VIRF-1 | Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus). | 31324791 | Activation of NIX-mediated mitophagy by an interferon regulatory factor homologue of human herpesvirus. | [Function][Subcellular location][Pathology & Biotech][Interaction] | Protein/gene_name: VIRF-1; HHV-8 K9. Function: In host cells, VIRF-1 binds directly to NIX and activates NIX-mediated mitophagy. Disease: Primary effusion lymphoma, Kaposi's sarcoma. Additional Annotation: Subcellular location: Host mitochondrion. | Young Bong Choi | 0000-0002-2523-1441 | 2020-12-2 |