UniProt AC | UniProt Status | Protein Name | Organism | PMID | Article Title | Category | Annotation | Contributor | ORCID | Submission Date | |
P02649 | Reviewed | Apolipoprotein E | Homo sapiens (Human). | 32588544 | Apolipoprotein E4 disrupts the neuroprotective action of sortilin in neuronal lipid metabolism and endocannabinoid signaling. | [Function][Pathology & Biotech] | Disease: The finding that the protective lipid pathway in APOE3 genotype in brain lipid metabolism is lost in carriers of the APOE4 genotype is relevant to sporadic Alzheimer's disease (AD). Additional Annotation: Identifies a novel protective lipid pathway, PUFA uptake pathway, linking neuronal APOE handling by sortilin with the well-known neuroprotective actions of PUFA (polyunsaturated fatty acids) in the brain. Loss of sortilin in APOE3 mice compromises this neuroprotective PUFA uptake pathway, suggesting sortilin as a key player in APOE-dependent lipid metabolism in the brain. | Xihan Qin | 0000-0003-1096-5941 | 2020-6-30 |