UniProt AC | UniProt Status | Protein Name | Organism | PMID | Article Title | Category | Annotation | Contributor | ORCID | Submission Date | |
P07237 | Reviewed | Protein disulfide-isomerase | Homo sapiens (Human). | 32149426 | Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress. | [PTM / Processing] | Additional Annotation: Its Ser357 can be phosphorylated by kinase FAM20C. Phosphorylation of PDI at Ser357 induces an open conformation of PDI and turns it from a "foldase" into a "holdase", which is critical for preventing protein misfolding in the ER. Phosphorylated PDI also binds to the lumenal domain of IRE1a, a major UPR signal transducer, and attenuates excessive IRE1a activity. | Jianchao Zhang | 0000-0002-3269-4639 | 2022-3-28 |