UniProt AC | UniProt Status | Protein Name | Organism | PMID | Article Title | Category | Annotation | Contributor | ORCID | Submission Date | |
P0DTC2 | Reviewed | Spike glycoprotein | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2). | 35215888 | Computational Analysis of Mutations in the Receptor-Binding Domain of SARS-CoV-2 Spike and Their Effects on Antibody Binding. | [Function][Pathology & Biotech] | Protein/gene_name: S. Function: Pathogen-derived receptor ligand activity (GO:0140295). Disease: COVID-19. Additional Annotation: Evidence:Computational analysis. | Amirah Ellis-Gilliam | 0009-0006-0769-8175 | 2023-5-29 | |
P0DTC2 | Reviewed | Spike glycoprotein | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2). | 36052466 | Persistent Circulating Severe Acute Respiratory Syndrome Coronavirus 2 Spike Is Associated With Post-acute Coronavirus Disease 2019 Sequelae. | [Pathology & Biotech] | Protein/gene_name: S. Disease: PASC (DOID:0080848). COVID-19 (DOID:0080600). Additional Annotation: Detection of circulating spike protein in PASC patients, suggesting a viral reservoir in the body of long COVID patients. | Amirah Ellis-Gilliam | 0009-0006-0769-8175 | 2023-5-29 | |
P0DTC2 | Reviewed | Spike glycoprotein | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2). | 36483199 | Conserved longitudinal alterations of anti-S-protein IgG subclasses in disease progression in initial ancestral Wuhan and vaccine breakthrough Delta infections. | [Function][Pathology & Biotech] | Protein/gene_name: S. Function: IgG binding (GO:0019864). Disease: COVID-19 (DOID:0080600). | Amirah Ellis-Gilliam | 0009-0006-0769-8175 | 2023-5-29 | |
P0DTC2 | Reviewed | Spike glycoprotein | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2). | 35300999 | The spike glycoprotein of SARS-CoV-2: A review of how mutations of spike glycoproteins have driven the emergence of variants with high transmissibility and immune escape. | [Function][Structure][Pathology & Biotech] | Protein/gene_name: S. Disease: COVID-19 (DOID:0080600). Additional Annotation: Review. | Amirah Ellis-Gilliam | 0009-0006-0769-8175 | 2023-5-29 | |
P0DTC2 | Reviewed | Spike glycoprotein | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2). | 35039785 | A comprehensive evolutionary and epidemiological characterization of insertion and deletion mutations in SARS-CoV-2 genomes. | [Pathology & Biotech] | Protein/gene_name: S. Disease: COVID-19 (DOID:0080600). Additional Annotation: Epidemiological study describing indel variants, with all major indel types identified here occurred at the NTD domain of S protein. | Amirah Ellis-Gilliam | 0009-0006-0769-8175 | 2023-5-29 | |
P0DTC2 | Reviewed | Spike glycoprotein | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2). | 37000302 | Insertion and deletion mutations preserved in SARS-CoV-2 variants. | [Pathology & Biotech] | Protein/gene_name: S. Disease: COVID-19 (DOID:0080600). Additional Annotation: Epidemiological study describing preserved indel mutations in Spike protein on SARS-Co-V2 sublineages. | Amirah Ellis-Gilliam | 0009-0006-0769-8175 | 2023-5-29 | |
P0DTC2 | Reviewed | Spike glycoprotein | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2). | 35660160 | Uncovering cryptic pockets in the SARS-CoV-2 spike glycoprotein. | [Structure][Pathology & Biotech] | Protein/gene_name: Spike glycoprotein; S. Additional Annotation: Molecular simulation study. | Amirah Ellis-Gilliam | 0009-0006-0769-8175 | 2023-5-29 | |
P0DTC2 | Reviewed | Spike glycoprotein | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2). | 34930824 | SARS-CoV-2 spike engagement of ACE2 primes S2' site cleavage and fusion initiation. | [Function][PTM / Processing][Interaction] | Protein/gene_name: Spike S. Function: Membrane fusion requires the proteolytic cleavage at the S2' site. Additional Annotation: R815 is a proteolytic cleavage site for S2' generation. | SHI YU | 0000-0003-0651-4769 | 2022-1-6 | |
P0DTC2 | Reviewed | Spike glycoprotein | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2). | 34548480 | Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential. | [PTM / Processing] | Additional Annotation: Signal peptide cleavage between amino acids 13-14. Pyroglutamate modification of Q14. Cathepsin L cleavage (calpeptin-sensitive) between amino acids 259-260 and 636-637. | Edward Emmott | 0000-0002-3239-8178 | 2021-10-11 | |
P0DTC2 | Reviewed | Spike glycoprotein | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2). | 32366695 | Site-specific glycan analysis of the SARS-CoV-2 spike. | [PTM / Processing][Structure] | Additional Annotation: There are two sites on SARS-CoV-2 S that are principally oligomannose-type: Asn-234 and Asn-709. A mixture of oligomannose- and complex-type glycans can be found at sites Asn-61, Asn-122, Asn-603, Asn-717, Asn-801 and Asn-1074. Of the 22 sites on the S protein, these 8 contain significant populations of oligomannose-type glycans. The remaining 14 sites are dominated by processed, complex-type glycans. | Ralf Stephan | 0000-0002-4650-631X | 2020-7-3 | |
P0DTC2 | Reviewed | Spike glycoprotein | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2). | 32422645 | Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody. | [PTM / Processing][Interaction][Structure] | Additional Annotation: CryoEM structure of human antibody S309 bound to SARS-CoV-2 S via recognition of a highly conserved epitope in the SB domain comprising the Asn-343-glycan. Glycan on Asn-343. PDB:6WPS, 6WPT. | Cecilia Arighi | 0000-0002-0803-4817 | 2020-5-20 | |
P0DTC2 | Reviewed | Spike glycoprotein | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2). | 32239522 | SARS-CoV-2 spike protein favors ACE2 from Bovidae and Cricetidae. | [Interaction][Structure] | Additional Annotation: Structural modeling of interaction of Spike protein receptor binding domain with ACE2 receptor from mammal, bird, turtle, and snake. | Cecilia Arighi | 0000-0002-0803-4817 | 2020-5-12 |