UniProt AC | UniProt Status | Protein Name | Organism | PMID | Article Title | Category | Annotation | Contributor | ORCID | Submission Date | |
P42345 | Reviewed | Serine/threonine-protein kinase mTOR | Homo sapiens (Human). | 35534828 | Identification of miRNA-mRNA-TF regulatory networks in peripheral blood mononuclear cells of type 1 diabetes. | [Function][Pathology & Biotech][Interaction] | Protein/gene_name: mTOR. Function: Activated mTORC1 regulates inflammatory immune responses in various innate immune cells. Disease: Diabetes Mellitus. Additional Annotation: The activation of mTORC1 signaling may also impair autophagic flux, consequently triggering the death of pancreatic B-cells and leading to T2D pancreatic islet failure or T1D. Namely, RRAGD may participate in the occurrence and development of diabetes by activating mTORC1. Specifically, mTORC1 inhibits apoptosis and induces macrophage proliferation by inducing the expression and metabolic reprogramming of the cell cycle kinase CDK4. | Andrew Fennimore | 0000-0002-5902-1215 | 2022-5-14 |