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UniProt AC
UniProt Status
Protein Name
Organism
PMID
Article Title
Category
Annotation
Contributor
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Submission Date
Q4J989ReviewedHomocitrate synthase Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770).31330039Biochemical characterization of archaeal homocitrate synthase from Sulfolobus acidocaldarius.[Function]Protein/gene_name: Homocitrate synthase; EC:2.3.3.14.
Function: Synthesis of homocitrate from acetyl-CoA and 2-oxoglutarate, the first (committed) step of lysine biosynthesis via the alpha-aminoadipate pathway. The enzyme is inhibited by lysine via its C-terminal RAM (Regulation of Amino acid Metabolism) domain.
Friedhelm Pfeiffer0000-0003-4691-32462019-10-14