UniProt AC | UniProt Status | Protein Name | Organism | PMID | Article Title | Category | Annotation | Contributor | ORCID | Submission Date | |
Q4J989 | Reviewed | Homocitrate synthase | Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770). | 31330039 | Biochemical characterization of archaeal homocitrate synthase from Sulfolobus acidocaldarius. | [Function] | Protein/gene_name: Homocitrate synthase; EC:2.3.3.14. Function: Synthesis of homocitrate from acetyl-CoA and 2-oxoglutarate, the first (committed) step of lysine biosynthesis via the alpha-aminoadipate pathway. The enzyme is inhibited by lysine via its C-terminal RAM (Regulation of Amino acid Metabolism) domain. | Friedhelm Pfeiffer | 0000-0003-4691-3246 | 2019-10-14 |