UniProt AC | UniProt Status | Protein Name | Organism | PMID | Article Title | Category | Annotation | Contributor | ORCID | Submission Date | |
Q62226 | Reviewed | Sonic hedgehog protein | Mus musculus (Mouse). | 31290579 | Chondrocyte-like nested cells in the aged intervertebral disc are late-stage nucleus pulposus cells. | [Expression] | Protein/gene_name: Shh. Disease: Intervertebral disc degeneration, degenerative disc disorder, back pain. Additional Annotation: Shh expression by the mouse nucleus pulposus cells declines with aging. Shh is expressed by a subset of nucleus pulposus cells in the aged mouse disc. | Chitra Dahia | 0000-0003-3683-9791 | 2020-5-6 | |
Q62226 | Reviewed | Sonic hedgehog protein | Mus musculus (Mouse). | 29784673 | Formation of the sacrum requires down-regulation of sonic hedgehog signaling in the sacral intervertebral discs. | [Function][Expression] | Protein/gene_name: Shh. Function: Shh regulates nucleus pulposus cell survival and extracellular matrix production by the sacral intervertebral disc. Disease: Intervertebral disc degeneration, degenerative disc disorder, back pain. Additional Annotation: Shh is expressed by the nucleus pulposus cells of the sacral intervertebral disc of the postnatal mouse. The expression of Shh is lost by skeletal maturity in the nucleus pulposus cells of the sacral intervertebral disc. | Chitra Dahia | 0000-0003-3683-9791 | 2020-5-6 | |
Q62226 | Reviewed | Sonic hedgehog protein | Mus musculus (Mouse). | 24892825 | Wnt signaling activates Shh signaling in early postnatal intervertebral discs, and re-activates Shh signaling in old discs in the mouse. | [Function][Expression] | Protein/gene_name: Shh. Function: Shh and Wnt axes regulate intervertebral disc cell proliferation and extracellular matrix production. Disease: Intervertebral disc degeneration, degenerative disc disorder, back pain. Additional Annotation: Shh is expressed by the nucleus pulposus cells of the postnatal mouse intervertebral disc. Shh expression reduces with age. | Chitra Dahia | 0000-0003-3683-9791 | 2020-5-6 | |
Q62226 | Reviewed | Sonic hedgehog protein | Mus musculus (Mouse). | 22558278 | Shh signaling from the nucleus pulposus is required for the postnatal growth and differentiation of the mouse intervertebral disc. | [Function][Expression] | Protein/gene_name: Shh. Function: Shh signaling regulates the proliferation of nucleus pulposus cells. Shh signals to the surrounding annulus fibrosus and endplate cells of the postnatal mouse intervertebral disc. Shh regulates extracellular matrix protein expression by the intervertebral disc cells. Disease: Intervertebral disc degeneration, degenerative disc disorder, back pain. Additional Annotation: Shh is expressed by the nucleus pulposus cells of the postnatal mouse intervertebral disc. | Chitra Dahia | 0000-0003-3683-9791 | 2020-5-6 | |
Q62226 | Reviewed | Sonic hedgehog protein | Mus musculus (Mouse). | 19212276 | Intercellular signaling pathways active during intervertebral disc growth, differentiation, and aging. | [Expression] | Protein/gene_name: Shh. Disease: Intervertebral disc degeneration, degenerative disc disorder, back pain. Additional Annotation: Shh is expressed by the nucleus pulposus cells of the postnatal mouse intervertebral disc. The expression of Shh reduces with age by the mouse nucleus pulposus cells. | Chitra Dahia | 0000-0003-3683-9791 | 2020-5-6 | |
Q62226 | Reviewed | Sonic hedgehog protein | Mus musculus (Mouse). | 19247165 | Postnatal growth, differentiation, and aging of the mouse intervertebral disc. | [Expression] | Protein/gene_name: Shh. Disease: Intervertebral disc degeneration, degenerative disc disorder, back pain. Additional Annotation: Shh is expressed by the postnatal mouse nucleus pulposus cells. | Chitra Dahia | 0000-0003-3683-9791 | 2020-5-6 |