UniProt AC | UniProt Status | Protein Name | Organism | PMID | Article Title | Category | Annotation | Contributor | ORCID | Submission Date | |
Q86TI2 | Reviewed | Dipeptidyl peptidase 9 | Homo sapiens (Human). | 29382749 | Structures and mechanism of dipeptidyl peptidases 8 and 9, important players in cellular homeostasis and cancer. | [Structure] | Protein/gene_name: DPP9. Function: Ligand binding to DPP9 induces an extensive rearrangement at the active site through a disorder-order transition of a 26-residue loop segment, which partially folds into an alpha-helix (R-helix), including Arg-133, a key residue for substrate binding. | Ruth Geiss-Friedlander | 0000-0002-1720-3440 | 2022-6-2 | |
Q86TI2 | Reviewed | Dipeptidyl peptidase 9 | Homo sapiens (Human). | 24562348 | The amino terminus extension in the long dipeptidyl peptidase 9 isoform contains a nuclear localization signal targeting the active peptidase to the nucleus. | [Subcellular location][Sequence] | Protein/gene_name: DPP9-L; DPP9-S. Additional Annotation: DPP9 is expressed as two isoforms. DPP9-L contains an N-terminal nuclear localization signal. DPP9-S is cytosolic. | Ruth Geiss-Friedlander | 0000-0002-1720-3440 | 2022-6-2 | |
Q86TI2 | Reviewed | Dipeptidyl peptidase 9 | Homo sapiens (Human). | 19667070 | [Function] | Protein/gene_name: DPP9. Function: DPP9 limits the presentation of the RU1 antigen on MHC class I alleles. | Ruth Geiss-Friedlander | 0000-0002-1720-3440 | 2022-6-2 | ||
Q86TI2 | Reviewed | Dipeptidyl peptidase 9 | Homo sapiens (Human). | 24072711 | The SUMO1-E67 interacting loop peptide is an allosteric inhibitor of the dipeptidyl peptidases 8 and 9. | [Function] | Protein/gene_name: DPP9. Function: DPP9 is a dipeptidyl peptidase that cleaves after prolines. Additional Annotation: The SUMO1-E67 interacting loop (EIL) and derivative peptides are inhibitors of DPP9 and DPP8. | Ruth Geiss-Friedlander | 0000-0002-1720-3440 | 2022-6-2 | |
Q86TI2 | Reviewed | Dipeptidyl peptidase 9 | Homo sapiens (Human). | 23152501 | A novel SUMO1-specific interacting motif in dipeptidyl peptidase 9 (DPP9) that is important for enzymatic regulation. | [Interaction][Structure][Sequence][Pathology & Biotech] | Protein/gene_name: DPP9. Function: DPP9 binds in a non-covalent manner to the E67 interacting loop (EIL) of SUMO1. Identification of the SUMO-binding arm in DPP9 (SUBA domain). SUMO1 acts as an allosteric regulator of DPP9. Additional Annotation: Mutation of Val-285 to Ala in DPP9 abolishes interaction with SUMO1. | Ruth Geiss-Friedlander | 0000-0002-1720-3440 | 2022-6-2 | |
Q86TI2 | Reviewed | Dipeptidyl peptidase 9 | Homo sapiens (Human). | 27614019 | DPP9 is a novel component of the N-end rule pathway targeting the tyrosine kinase Syk. | [Function][Subcellular location][PTM / Processing][Interaction] | Protein/gene_name: DPP9. Function: DPP9 regulates B-cell receptor mediated signaling by processing SYK N-terminus. DPP9 plays a role in the N-degron pathway. | Ruth Geiss-Friedlander | 0000-0002-1720-3440 | 2022-6-2 |