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UniProt AC
UniProt Status
Protein Name
Organism
PMID
Article Title
Category
Annotation
Contributor
ORCID logoORCID
Submission Date
Q8C267ReviewedHistone-lysine N-methyltransferase SETDB2 Mus musculus (Mouse).31350176The Histone Methyltransferase Setdb2 Modulates Macrophage Phenotype and Uric Acid Production in Diabetic Wound Repair.[Function][Pathology & Biotech][Expression]
Function: SETDB2 regulates macrophage plasticity during normal and pathologic wound repair.
genevieve fourel0000-0003-4050-84422021-2-7
Q8C267ReviewedHistone-lysine N-methyltransferase SETDB2 Mus musculus (Mouse).26709698Type I Interferon Induced Epigenetic Regulation of Macrophages Suppresses Innate and Adaptive Immunity in Acute Respiratory Viral Infection.[Function][Pathology & Biotech][Expression]
Function:SETDB2 seems to play a role as a regulator of the immune system in acute respiratory viral infection. It is an ISG (interferon stimulated gene), induced late during the secondary response (IFNAR dependent), and appears to play a role as a paradoxical component in the system, presumably aiding in putting an end to the interferon response. As such, it appears to adversely promote IAV replication, as it is over-expressed over an extended period upon IAV infection).
genevieve fourel0000-0003-4050-84422021-2-7
Q8C267ReviewedHistone-lysine N-methyltransferase SETDB2 Mus musculus (Mouse).25419628The methyltransferase Setdb2 mediates virus-induced susceptibility to bacterial superinfection.[Function][Pathology & Biotech][Expression]
Function: SETDB2 is an ISG (interferon stimulated gene), induced late during the secondary response (IFNAR dependent), and appears to play a role as a paradoxical component in the system, presumably aiding in putting an end to the interferon response. As such, it appears to adversely promote bacterial super-infection occurring after influenza infection.
genevieve fourel0000-0003-4050-84422021-2-7
Q8C267ReviewedHistone-lysine N-methyltransferase SETDB2 Mus musculus (Mouse).27568546SETDB2 Links Glucocorticoid to Lipid Metabolism through Insig2a Regulation.[Function][Pathology & Biotech][Expression]
Function: SETDB2 somehow promotes trimethylation of H3K9, but it is not a histone methyl-transferase itself.
genevieve fourel0000-0003-4050-84422021-2-7