UniProt AC | UniProt Status | Protein Name | Organism | PMID | Article Title | Category | Annotation | Contributor | ORCID | Submission Date | |
Q8C267 | Reviewed | Histone-lysine N-methyltransferase SETDB2 | Mus musculus (Mouse). | 31350176 | The Histone Methyltransferase Setdb2 Modulates Macrophage Phenotype and Uric Acid Production in Diabetic Wound Repair. | [Function][Pathology & Biotech][Expression] | Function: SETDB2 regulates macrophage plasticity during normal and pathologic wound repair. | genevieve fourel | 0000-0003-4050-8442 | 2021-2-7 | |
Q8C267 | Reviewed | Histone-lysine N-methyltransferase SETDB2 | Mus musculus (Mouse). | 26709698 | Type I Interferon Induced Epigenetic Regulation of Macrophages Suppresses Innate and Adaptive Immunity in Acute Respiratory Viral Infection. | [Function][Pathology & Biotech][Expression] | Function:SETDB2 seems to play a role as a regulator of the immune system in acute respiratory viral infection. It is an ISG (interferon stimulated gene), induced late during the secondary response (IFNAR dependent), and appears to play a role as a paradoxical component in the system, presumably aiding in putting an end to the interferon response. As such, it appears to adversely promote IAV replication, as it is over-expressed over an extended period upon IAV infection). | genevieve fourel | 0000-0003-4050-8442 | 2021-2-7 | |
Q8C267 | Reviewed | Histone-lysine N-methyltransferase SETDB2 | Mus musculus (Mouse). | 25419628 | The methyltransferase Setdb2 mediates virus-induced susceptibility to bacterial superinfection. | [Function][Pathology & Biotech][Expression] | Function: SETDB2 is an ISG (interferon stimulated gene), induced late during the secondary response (IFNAR dependent), and appears to play a role as a paradoxical component in the system, presumably aiding in putting an end to the interferon response. As such, it appears to adversely promote bacterial super-infection occurring after influenza infection. | genevieve fourel | 0000-0003-4050-8442 | 2021-2-7 | |
Q8C267 | Reviewed | Histone-lysine N-methyltransferase SETDB2 | Mus musculus (Mouse). | 27568546 | SETDB2 Links Glucocorticoid to Lipid Metabolism through Insig2a Regulation. | [Function][Pathology & Biotech][Expression] | Function: SETDB2 somehow promotes trimethylation of H3K9, but it is not a histone methyl-transferase itself. | genevieve fourel | 0000-0003-4050-8442 | 2021-2-7 |