Function: Induces the nucleation of a endosomal- and microtubule-localized signalosome that transmits pro-inflammatory signaling postively regulated by LUBAC and TRAF6. Independently of NF-kappaB, induces hyperproliferative phenotype and PI3K/Akt - mTOR signalling in the skin. Interacts with TRAF2, TRAF6, HOIP/RNF31, HOIL-1, SHARPIN, A20, ABIN1, cIAP1, cIAP2, DIABLO, AP2M1, AP2B1, AP2A1, AP2S1, EpsinR and Clathrin. Additional Annotation: Subcellular location: Activated protein is localized on microtubules and endosomes.
Anonymous
Anonymous
2024-8-23
Status
What does it mean?
Who can view these?
Public
The publication can be accessed in the entry publication page on the UniProt website
Everyone
Reviewed
The submission has been reviewed by curators.
Submitter (need to sign in with ORCID)
Under Review
The submission has not yet been reviewed by UniProt and it is not ready for release
Submitter (need to sign in with ORCID)
Dropped
The submission has been found to be inappropriate (e.g., incorrect association of paper to entry)