UniProt AC | UniProt Status | Protein Name | Organism | PMID | Article Title | Category | Annotation | Contributor | ORCID | Submission Date | |
Q9H2V7 | Reviewed | Protein spinster homolog 1 | Homo sapiens (Human). | 37075117 | An SPNS1-dependent lysosomal lipid transport pathway that enables cell survival under choline limitation. | [Function][Subcellular location][Pathology & Biotech] | Protein/gene_name: SPNS1. Function: Proton-dependent lysosomal transporter for lysophospholipids, in particular lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE). Exports LPC and LPE from the lysosomal lumen to the cytosol. Plays a critical role in recycling choline-containing lipids and becomes essential for cell survival when the availability of free choline in the environment is limited. | Anonymous | Anonymous | 2023-5-11 |