UniProt AC | UniProt Status | Protein Name | Organism | PMID | Article Title | Category | Annotation | Contributor | ORCID | Submission Date | |
Q9HAI6 | Reviewed | TLR adapter interacting with SLC15A4 on the lysosome | Homo sapiens (Human). | 32433612 | TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7-9. | [Function][Subcellular location][Pathology & Biotech][Expression][Interaction] | Protein/gene_name: TASL; CXorf21. Function: CXorf21/TASL acts as an innate immune adaptor meditating the activation of IRF5 downstream of endolysosomal TLR7-9 activation. IRF5 recruitment is mediated by a pLxIS motif (where p and x denote hydrophilic and any amino acid, respectively) present in the C-terminal region of CXorf21/TASL. CXorf21/TASL interacts with SLC15A4. Binding to SLC15A4 is required for the recruitment of CXorf21/TASL to endolysosomes. Disease: Systemic lupus erythematosus. | Manuele Rebsamen | 0000-0001-6172-4211 | 2020-9-18 |