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UniProt AC
UniProt Status
Protein Name
Organism
PMID
Article Title
Category
Annotation
Contributor
ORCID logoORCID
Submission Date
Q9NPP4ReviewedNLR family CARD domain-containing protein 4 Homo sapiens (Human).35462504[Identification of rare variants in exons of NLRC4 gene in patients with type 1 diabetes and their impact on gene function].[Function][Pathology & Biotech][PTM / Processing][Sequence]Protein/gene_name: NLR family CARD domain-containing protein 4; NLRC4.
Function: Several NLRC4 rare variants may have an impact on gene function and secretion of IL-1B.
Disease: Type 1 diabetes.
Additional Annotation: NLRC4 gene rare variants c.208C>T, c.1564T>C and c.1219G>C may not change the protein expression, degradation and localization, but c.208C>T and c.1219G>C may inhibit the secretion of IL-1B.
Andrew Fennimore0000-0002-5902-12152022-5-7